The human energy metabolism laboratory consists of gas generation and sampling system, gas analysis system (including dual channel oxygen analyzer, CO2 analyzer) Composed of analyzers and water vapor analyzers, data acquisition and processing systems, etc., using the gold standard indirect calorimetry method, the subjects can freely move (metabolic chamber type) or wear respiratory masks (or canopies), and can be optionally equipped with infrared thermography, activity intensity and temperature recorders, etc., to comprehensively measure the energy metabolism level of the human body in different states, in order to study the human response (adaptation) to different ecological environmental conditions, including survival restrictions and stress, energy acquisition and distribution (for maintenance and production consumption), and its significance for human well-being and health (including human survival and reproduction), such as energy metabolism research on different foods and their eating patterns, different living conditions including modern transportation such as railways and automobile environmental conditions. Energy metabolism response Energy metabolism research on obesity and related metabolic diseases (such as cardiovascular disease, diabetes, osteoporosis, some cancers, etc.).

The main technical features are as follows:

1) Modular structure, free combination and flexible configuration, with strong scalability, can be easily combined for energy metabolism measurement in experimental animals, etc

2) Flow measurement technology, real-time observation and analysis

3) Modular differential CO2, O2, and water vapor pressure measurement system, optionally equipped with an integrated three parameter gas analyzer

4) Optional respiratory mask or canopy

5) Quick response, gas analysis response time less than 1 second, allowing for real-time reflection of instantaneous changes in breathing

6) Equipped with a wearable activity data collector, it automatically collects three-dimensional activity data, temperature (body surface temperature), humidity (body surface humidity), etc

7) Optional infrared thermal imaging unit for imaging measurement of surface and environmental temperature distribution, to study and analyze the relationship between surface heat dissipation temperature distribution and environmental temperature

8) Optional hyperspectral imaging system for skin phenotype analysis, pathological section hyperspectral imaging, etc.

9) Can be used in biomedical, translational medicine, clinical diagnostic measurement, exercise physiology, environmental physiology research, etc

Main technical indicators:

1. Differential Oxygen Analysis Module: Fuel Cell O₂Analytical technology, unaffected by water vapor, CO2, and other gases, measurement range 1-100%, resolution 0.0001%, low noise and high stability, accuracy better than 0.1%, response time less than 7 seconds, 24-hour drift less than 0.01%, 20 minute noise less than 0.002% pk pk; Temperature and pressure compensation, 4-channel analog output, 16 bit resolution; Digital filtering (noise) adjustable from 0-50 seconds, amplification of 0.2 seconds, built-in A/D converter resolution of 24 bits; Can simultaneously measure temperature (measurement range 0-60 ℃, resolution 0.001 ℃) and air pressure (measurement range 30-110kPa, resolution 0.0001kPa); Equipped with a two-line text digital LCD display screen, backlit, capable of displaying both oxygen content and air pressure simultaneously;

2. Carbon dioxide measurement and analysis: Dual wavelength non dispersive infrared technology, measurement range 0-5% or 0-15% two-stage selection (two-way), built-in data acquisition system, real-time measurement, response time less than 1 second, resolution better than 0.0001% or 1ppm (up to 0.1ppm), accuracy 1%, recommended air flow 5-2000ml/minute, noise less than 2ppm, 24-hour drift less than 0.002%, temperature and pressure compensation, sampling frequency 10Hz; with two lines of text digital LCD display screen, backlight, can display CO simultaneously₂Content and pressure; 4-channel analog output, 16 bit resolution, with digital filtering (noise)

3. Water vapor measurement analysis: thin film capacitive sensor, measuring unit is relative humidity or dew point temperature or water vapor partial pressure, measuring range is 0-100% RH, resolution is 0.001% RH, 0.01 ℃ dew pointPoint temperature, accuracy 1%, drift below 0.01% per hour at constant temperature

4. Gas secondary sampling unit: including a pump, needle valve (controlling the airflow in and out of the pump body), and gas flow meter (0-2000ml/m); Diaphragm pump, roller motor, maximum flow rate 2-4L/min; Thermal bridge flowmeter with a resolution of 1ml/min and an accuracy of 2%; Analog output 12 bits

5. Data acquisition unit, 12 channels, 8 analog inputs, 16 bit resolution; 4 temperature inputs with a resolution of 0.001 degrees Celsius; 8 digital outputs for system control, 1 16 bit counter, 2 channel voltage outputs, pulse width modulation;

6. The software can display and analyze data online

7. Thermistor probe is used to measure the temperature inside the breathing room and the air temperature: measurement range -5-60 ℃, resolution 0.001 ℃, absolute accuracy 0.2 ℃, BNC connection, probe diameter 2.5mm;

8. Airflow control monitoring unit: flow rate 75-500L/min, resolution 1L/min, accuracy 2% of full range;

9. Wearable data collector: temperature measurement range -40 ° C-125 ° C, accuracy 0.2 ° C; humidity measurement range 0-100%, accuracy ± 1.8%; Three dimensional acceleration sensor (activity monitoring) with a measurement range of ± 15g and an accuracy of ± 0.15g, equipped with an OLED color display screen to display measurement data and charts, and Bluetooth communication

Main references:

1) Edward L. Melanson etc. A new approach for flow-through respirometry measurements in humans. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010

2) Rachel R. Markwald etc. Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. PNAS, 2012

3) Kate Lyden etc. Estimating Energy Expenditure Using Heat Flux Measured at Single Body Site. Med Sci Sports Exerc. 2014

4) Andrew W. McHill etc. Impact of circadian misalignment on energy metabolism during simulated nightshift work. PNAS, 2014

Attachment: EcoTron human energy metabolism chamber

The human energy metabolism chamber is a cabin style measurement and observation system for human energy metabolism, mainly composed of a metabolism chamber or climate chamber, CO2/O2 analyzer, gas circulation sampling system, etc. It can measure and observe the physiological ecology of energy consumption in the human body under natural or exercise conditions and different intervention conditions. It is the "gold standard" for monitoring human energy metabolism and is applied in fields such as obesity, diabetes, endocrine metabolism, nutrition, different environmental simulation physiology, aging and metabolism, exercise physiology, and observation of traditional Chinese medicine treatment processes.

Yiketai Ecological Technology Company provides a comprehensive solution for human energy metabolism cabin, with the main technical features of:

1) Diversified gas analysis and monitoring system, including CO2, O2, H2O (water vapor), optional flow formula CO2/O2 analysis sensor or diffusion CO2/O2 analysis sensor

2) Different types of metabolic chambers can be optionally selected, such as simple airtight chambers with gas circulation or climate chambers with environmental simulation control. The climate chamber can regulate temperature, humidity, lighting, and CO2, and the intelligent LED light source can perform day night automatic simulation, cloud weather simulation, etc

3) Optional containerized climate chamber for convenient transportation,Ecological environment simulation experiments can be conducted and observed at any location and under any environmental conditions

4) Optional infrared thermal imaging observation unit, online observation and analysis of surface heat dissipation, spatiotemporal dynamic distribution of body temperature, respiration, physiological ecology, and psychological dynamic analysis, etc

5) Optional wearable temperature and activity data collector, high time resolution monitoring of three-dimensional activity of different parts of the body, multi-point temperature, and sweating situation, etc